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The G protein-coupled receptor of GLP-1 (GLP-1R) originally identified in islet -cells is widely expressed in extrapancreatic tissues as well including the lungs, kidney, brain, the enteric and peripheral nervous system, lymphocytes, smooth muscle cells (SMCs), and atrial cardiomyocytes [32] The specific identity of GLP-1 receptor-positive (GLP-1R+) cells in the heart remains uncertain

Successful clinical translation necessitates further in vivo studies that assess significantly later time points

Nausea is common with all GLP-1 medications, though its intensity and duration can vary

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