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1 Introduction Diabetes mellitus (DM) is a chronic disease of the endocrine system characterized by hyperglycemia mainly induced by insufficient insulin secretion or insulin resistance ( Glucagon-like peptide-1 (GLP-1) is a peptide secreted by the intestinal tract after the stimulation of food intake, which induces the secretion of insulin by cells, thus modulating blood glucose ( This narrative review aimed to summarize the currently available perspective on the potential involvement of GLP-1R agonists in DPN and shed light on the future direction of clinical studies

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