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Moreover, systemic metabolic rate was found to be continuously rising owing to the systemic inflammation, so the amount of oxygen transported by hemoglobin cannot meet the bodys metabolic needs
Disadvantages: Only fraction of injected dose reaches eyes (most distributed to other tissues)
One is that GSSG and GS-X produced in cardiomyocytes are pumped out by multidrug resistance protein 1 (MRP1), preventing GSSG or GS-X accumulation in cardiomyocytes [33, 34], and subsequently enter the -glutamyl cycle
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