CMA is conventionally regarded as a pro-survival mechanism, activated under conditions such as starvation, and dependent on both HSP70swhich bind client proteinsand HSP90s, which stabilize LAMP2A (Tekirdag and Cuervo, 2018)
However, we are sensitive to payment disparities the commenter raises between the OPPS and ASC payment system and will continue to monitor this issue and consider the commenter's recommendation in future rulemaking
Acknowledgements The authors work was supported in part by research grants from the German Heart Foundation/German Foundation of Heart Research (Josef Freitag Foundation to A.G., F/08/14 to D.T., F/03/15 to D.L.), from the Else Krner-Fresenius-Stiftung (2014_A242 to D.T., 2014_A306 to D.L., 2016_A20 to N.V.), from the Joachim Siebeneicher Foundation (to D.T.), from the Deutsche Forschungsgemeinschaft (German Research Foundation
It essentially puts them in a state of suspended animation, stopping proliferation in its tracks
