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We continue to believe that if market-based data (median payer-specific negotiated charges for MA organizations) are incorporated into the calculation of the MS-DRG relative weights, initially there will be limited impact on the relative weights given the current similarity between MA organization rates and Medicare FFS rates, but that over time the proposal would create an opportunity for negotiations to reflect market dynamics, as noted by a commenter who supported our proposed policy

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These L-cells are equipped with specific G-protein-coupled receptors, namely FFAR2 (GPR43) and FFAR3 (GPR41), which are biologically designed to "taste" microbial metabolites