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Pancreas GLP-1 and GIP stimulate insulin secretion GLP-1 suppresses glucagon secretion during hyperglycemia GIP suppresses glucagon secretion during hyperglycemia and stimulates secretion during euglycemia and hypoglycemia Brain GLP-1 and GIP suppress hunger Stomach GLP-1 slows gastric emptying Fat tissue GIP increases fatty acid and glucose uptake by fat tissue [1,2,3] Tirzepatide Tirzepatide is a dual GLP-1 / GIP receptor agonist that mimics the actions of GLP-1 and GIP

10.2147/DDDT.S284163 79 XuC.SunL.RenF.HuangP.TianZ.CuiJ.et al (2020)