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Adverse Reactions/Side Effects In most cases, methylcobalamin is nontoxic, even in large doses

GLS expression is increased post-castration in LNCaP and LAPC4 xenografts (61), and pharmacological inhibition of GLS1 reduces the tumor burden in PC3, but not LNCaP xenografts (61), highlighting the dependency on glutamine metabolism in AR-negative, hormone-insensitive prostate cancer (61)

Despite this, its biological effects on gene expression and telomerase activation persist for extended periods, suggesting a hit-and-run mechanism where transient peptide exposure triggers sustained downstream signaling

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