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APAP adducts on mitochondrial proteins such as glycine amidinotransferase, Parkinson disease protein 7 (PARK7), peroxiredoxin 6 and voltage-dependent anion-selective channel protein 2 (VDAC2) have also been detected in cultures of human hepatocytes [34], indicating that adduct formation is not a global phenomenon affecting all mitochondrial proteins, but rather selective with specific targets

Practical consideration: Liposomal formulations are typically more expensive

These compounds work through independent mechanisms, meaning they can potentially be used together under physician supervision without pharmacological conflict

Casara Andre in conversation with Earth Buddy founder Sean Zyer