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Health Perspect, 100: 45-56
It is 3771.5, nearly double the additive prediction
The drug is a synthetic version of the venom's hormone, developed by scientists to mimic the effects of GLP-1, which boosts the body's ability to release its own insulin
The key pathways including lipotoxicity and oxidative stress (involving NLRP3 inflammasome, MAPK, PI3K/Akt, and RAAS signaling), inflammation (via NF-B, NLRP3 inflammasome, JAK-STAT, Toll-like receptor, and cGAS-STING pathways), and fibrosis/ECM production (driven by TGF-, Wnt, RAAS, and Notch signaling) have been identified and reported in CKD progression [235]
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