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Preclinical studies have indicated that these compounds markedly improve intervertebral disc structure and suppress inflammatory responses in animal models of IDD, highlighting their potential clinical applications (47,88)

For example, cystic fibrosis patients suffer from severe gram-negative bacterial infections and are commonly prescribed the aminoglycoside antibiotics amikacin or tobramycin, despite as high as a 14% incidence of hearing loss (Cheng et al., 2007