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The STAMPEDE trial showed that at five years, 29% of gastric bypass patients and 23% of sleeve gastrectomy patients achieved normal glucose levels without any diabetes medications

6 In the EXAMINE trial, a safety signal for increased risk of hospitalisation for heart failure was identified with alogliptin, particularly in people with a history of heart failure

those who took tirzepatide and semaglutide were projected to regain about 1.8 pound per month and to return to their baseline weight within about 1.5 years

speculated that ghrelin resistance observed in patients with cancer cachexia may be similar to insulin resistance in patients with type 2 diabetes mellitus, which can be mitigated by treatment with high doses of insulin (91)