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In periods of nutritional deficiency, stress, increased reactive oxygen species (ROS), toxicity, mitochondrial dysfunction, cellular proliferation, Phase 2 detoxification, etc

Forecasting analysis predicts that both incidence and mortality will continue to rise over the next three decades, reaching their peaks by 2049, particularly in older age group [41]

These observations describe outcomes reported in laboratory and animal research models only

These new discoveries, together with the in-depth preclinical characterization of NAD + modulators and ongoing developments in their translation in humans, will open further avenues of study of this essential cofactor and its clinical therapeutic potential