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Also, because GLP-1 drugs engage the brains reward circuitry the same system that governs not just craving but everyday motivation prolonged use could, in theory, dampen motivational drive in some people

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A randomized clinical trial to determine the effect of dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonist-mediated weight loss and diet on crohn's disease clinical response: a pilot study

Firstly, restricted carbohydrate intake in KD leads to a reduction in glycolysis, the primary pathway of glucose catabolism, which is responsible for the production of NADH (140)