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This layer contains loose connective tissue with relatively poor structural support, allowing blood to spread more easily compared to deeper, more densely organized tissues

Similarly, the c-MYC proto-oncogene is known to upregulate glutamine metabolism, specifically regulating GLS1, SLC1A5 and many of the genes involved in proline, nucleotide and serine biosynthesis (Wise et al, 2008

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870 Exposure of chondrocyte to excessive mechanical load leads to increased catabolism