dr guenter klow Spanking and The Man with 1000 Names

That matters because oxidative stress can affect how well the body maintains balance, energy, and overall metabolic health

These include ribosome-associated quality control during protein synthesis, molecular chaperone systems such as heat shock proteins that ensure proper folding and conformational stability and intracellular trafficking pathways that guide nascent proteins to their correct destinations

Similarly, silymarin protected against ischemia-reperfusion injury, a pro-oxidative state and a major contributor to acute kidney injury, when given to rats at a dose equivalent to about 567 mg for an adult human (Senturk 2008)

Your body adapted to the previous dose