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Enhanced D1 receptor signaling would also explain why addicts are more prone to relapse when stressed or hungry, both conditions that augment ghrelin secretion and sensitivity (Carroll, 1985

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When triggered by peptides like -MSH or melanotan, these receptors start a process inside the cell that leads to increased melanin production

This rapid shift occurs because the medication activates GLP-1 receptors in the brain's appetite centers, signaling satiety even when less food is consumed