At the outset of the project, in 2020, a targeted literature review was performed, for each endpoint, utilising expert knowledge in the fields of nuclear receptor activation, adipogenesis, nutrition and metabolic disruption, together with (guidance from) highly relevant well-documented reviews, to focus and retrieve pertinent chemical and target endpoint literature evidence
It shows up wherever the body is under oxidative pressure, which means it's active across several systems at once
The expression levels of cross-linking enzymes and structural proteins produced by cellssuch as keratin laminin, filaggrin (FLG), transglutaminase-1, and keratin filamentthat are related to skin barrier function are downregulated under the action of ROS, thereby impairing skin barrier function ( FIGURE 5 4 Therapeutic strategies based on ROS regulation With the deepening understanding of the role of ROS in skin diseases, various therapeutic strategies targeting ROS regulation have been developed
Berry juices (golden raspberry, red raspberry, blackberry, blueberry, cherry, and strawberry) contained 722% less folate than berries 37
