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Neurosurgery 28 (15), 17 (2006)

While others have reported on the significant MACE reduction with GLP-1RA therapy in the secondary prevention cohort, but not in the primary prevention setting [91], our findings extend the current notion that the beneficial impact on the individual MACE constituents, particularly MI risk reduction, may be attenuated in the higher risk secondary preventative population with established CVD, often characterized by advanced age and multimorbidity status [90]

And as far as anti-aging, while Protandim may have increased lifespan in male rats by 7%, why havent they reproduced these results in humans

It has been established that Circ_0001093 and miR-579-3p are in mutual negative feedback, and that, in conjunction with GLS, the three form the Circ_0001093/miR-579-3p/GLS regulatory network