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In the SELECT trial, which included more than 17,000 patients with obesity and cardiovascular disease but not diabetes, semaglutide cut the rate of major cardiac events by 20%

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Even if only a fraction of those patients sought GLP-1 treatment, insurers could face billions of dollars in additional costs

ADA 2026 emphasizes individualized care in older adults, with attention to nutrition, functional status, and overtreatment avoidance Thyroid caution Avoid in: Medullary thyroid carcinoma (MTC) MEN-2 syndrome This remains a boxed warning / contraindication in current labels