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Annual review of microbiology , 54, 439461

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The peptide has likely lost 1020% potency and should be used immediately or discarded

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Electrophysiological recordings further supported this, revealing that Dihexa caused a 1.6-fold increase and Nle-AngIV caused a 1.7-fold increase in the frequency of AMPA-mediated mEPSCs compared to vehicle-treated neurons, indicating an expansion of functional synapses without altering individual synapse properties such as amplitude, rise, or decay times

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Clinical trials have extended beyond two years, and the safety profile appears acceptable for ongoing use

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