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Risk increases with: Too few calories or skipped meals , leading to protein breakdown for energy Inadequate protein intake , especially near minimal dietary requirements rather than weight-lossappropriate targets Lack of resistance training , removing the signal to maintain muscle Micronutrient deficiencies , such as low vitamin D, which can impair muscle function Preventing undernutrition dramatically reduces the risk of clinically meaningful muscle loss. How Common Is Lean-Mass Loss with GLP-1/GIP Therapy
Marini, C
This early response involves proximal small-intestinal L-cells alongside neural and hormonal signals, including vagal nerve activation and the release of gastric hormones
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