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1 Introduction Drugs that activate the glucagon-like peptide-1 (GLP-1) receptor are currently used clinically to treat type 2 diabetes mellitus (T2DM) and obesity ( The GLP-1 and GIP receptors (GLP-1R and GIPR, respectively) are closely related members of family B or the secretin class of G protein-coupled receptors (GPCRs) and share a high degree of sequence homology ( The reasons why GLP-1, but not GIP, remains insulinotropic in T2DM are still unclear but may be related to the receptors differing signaling profiles ( s , resulting in an increase in intracellular cyclic adenosine monophosphate (cAMP)

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doi: 10.1016/j.abb.2009.03.001

Evans, R